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48-FOLD PARALLELIZED MICRO FERMENTATION SYSTEM FOR EFFICIENT DEVELOPMENT OF BIOPROCESSES
By combining micro system processing, biochemical engineering know-how and high sensitive noninvasive optical sensor technique, an innovative 48-fold parallelized milliliter fermentation system could be created. Designed for the scale-down of biotechnological production processes into the milliliter-scale, developed for efficient process development and high throughput screenings in the biotechnological, chemical and pharmaceutical research, simple handling with very high time and cost savings due to the parallelization and miniaturization.

2mag bioREACTOR 48
Space-saving, user-friendly and easy manageable minifermenter with 48 miniaturized, inductive wear-free and maintenance-free magnetic stirrers, optimized for the transformation of biotechnological production processes into the milliliter-scale, very high time, material and cost savings due to the miniaturization, efficient optimization and development of bioprocesses due to the parallelization.

Sterilizable, space-saving bioreaction system for strictly reproducible fermentation results in the milliliter-scale by precise temperature control up to 65°C, exactly adjustable stirring speed up to 4,000 rpm and automatic stirrer monitoring as well as precise noninvasive realtime measurement of pH and dissolved oxygen (PreSens sensor technology).

Cultivation of most diverse microorganisms (e.g. yeast, fungi, bacteria) up to high cell densities ensured by a maximal variability of the adjustable process parameters as well as the high oxygenation capacity of the gas inducing stirring elements.

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Sterile headspace aeration with variable volumetric flow rates prevents cross and external contaminations. Integrated exhaust gas cooling minimizes occuring evaporation losses. Easy realizable high throughput experiments due to parallelization allow highly reduced development time for new production processes. Miniaturization into the low milliliter-scale (8 - 15 ml) guarantees enormous material and cost savings.

Simple scaling-up of the results into production scale due to precisely defined engineering parameters and the comparable power and oxygen input to well-established stirred tank reactors. The bioREACTOR can be operated as standalone or fully automated by integration into a pipetting robot (Tecan).

 

2mag bioREACTOR application examples >>

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